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- Dongli Li, Yuran Ma, Wenfeng Liu, Xiang Ren, Min Chen, Xuetao Xu, Zhaojun Sheng, Kun Zhang, Renping Zhou, Susan Goodin, and Xi Zheng.
- School of Biotechnology and Health Sciences, Wuyi University, Jiangmen city, 529020, China.
- Int J Med Sci. 2020 Jan 1; 17 (12): 1795-1802.
AbstractBackground/Aim: Pancreatic adenocarcinoma is a highly malignant tumor. Synergistic combinations of anticancer agents for the effective treatment of pancreatic cancer patients are urgently needed. Here, we investigated the combined effect of celecoxib (CEL) and salirasib (SAL) on pancreatic cancer cells. Methods: Cell viability and apoptosis were measured by the trypan blue assay, three-dimensional cultures, propidium iodide staining, and caspase-3 assay. NF-κB activation and the protein levels of Akt, pAkt, and Bcl-2 were determined by the luciferase reporter assay and western blot. Results: Co-treatment with CEL and SAL had stronger effects on decreasing cell viability and inducing apoptosis in Panc-1 cells as compared with each agent individually. This combination strongly inhibited NF-κB activity and reduced pAkt and Bcl-2 levels in Panc-1 cells. Conclusion: SAL in combination with CEL may represent a new approach for effective inhibition of pancreatic cancer.© The author(s).
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