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Randomized Controlled Trial
Does concurrent use of clopidogrel and PPIs increase CV risk in patients with ACS?
- Sandy Shehata, Jason Baker, Gary Kelsberg, and Sarah Safranek.
- Valley Medical Center, Renton, WA, USA.
- J Fam Pract. 2020 Jul 1; 69 (6): 309;310;315.
AbstractNo. Adding a proton pump inhibitor (PPI) in patients taking antiplatelet medications such as clopidogrel for acute coronary syndrome (ACS) doesn't increase the composite risk of cardiovascular (CV) events: CV death, myocardial infarction (MI), and cerebrovascular accident (CVA) (strength of recommendation: B, randomized, controlled trial [RCT] and prepon-derance of posthoc analyses of large RCTs).
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