The Journal of family practice
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Randomized Controlled Trial
Does concurrent use of clopidogrel and PPIs increase CV risk in patients with ACS?
No. Adding a proton pump inhibitor (PPI) in patients taking antiplatelet medications such as clopidogrel for acute coronary syndrome (ACS) doesn't increase the composite risk of cardiovascular (CV) events: CV death, myocardial infarction (MI), and cerebrovascular accident (CVA) (strength of recommendation: B, randomized, controlled trial [RCT] and prepon-derance of posthoc analyses of large RCTs).
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Here's what the evidence tells us about the use of 2 regimens-clopidogrel + aspirin and ER dipyridamole + aspirin-to prevent secondary ischemic stroke.
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This review will help you troubleshoot everything from infections and foreign bodies to trauma and neoplasm.