• Yong-Bo Guo, Yan Liu, Jing Ma, Ying Cai, Xiao-Ming Jiang, and Hong Zhang.
• Department of Critical Care Medicine, The Affiliated Hongqi Hospital of Mudanjiang Medical University.
• Medicine (Baltimore). 2020 Aug 7; 99 (32): e21569.

BackgroundThis study aims to assess the effect of early enteral nutrition support (EENS) for the management of acute severe pancreatitis (ASP).MethodsThis study will search Cochrane Library, PUBMED, EMBASE, Cumulative Index to Nursing and Allied Health Literature, Allied and Complementary Medicine Database, CNKI, and WANGFANG from their inception to the present without language limitations. In addition, this study will also search clinical trial registry and reference lists of included trials. Eligible comparators will be standard care, medications, and any other interventions. Two authors will independently scan all citations, titles/abstracts, and full-text studies. The study methodological quality will be appraised using Cochrane risk of bias tool. If it is possible, we will pool out data and perform meta-analysis. Strength of evidence for each main outcome will be evaluated using the Grading of Recommendations Assessment, Development, and Evaluation.ResultsThis study will summarize the most recent evidence to assess the effect of EENS for the management of ASP.ConclusionThe findings of this study will help to determine whether EENS is effective for patients with ASP.Study RegistrationINPLASY202070009.

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