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- Hyun Min Koh and Dong Chul Kim.
- Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon.
- Medicine (Baltimore). 2020 Aug 7; 99 (32): e21575.
BackgroundRecent studies showed that Macrophage migration inhibitory factor (MIF) is overexpressed and closely associated with prognosis in cancer patients. The present study was systematically evaluated the prognostic significance of MIF expression in cancer patients.MethodsPubMed, Cochrane library and Scopus were searched for eligible studies up to January 2020. Pooled hazard ratio with confidence interval (CI) was determined to assess the relationship between MIF expression and survival in cancer patients.ResultsA total of 8 studies comprising 847 cancer patients were included in this meta-analysis. For overall survival, the pooled hazard ratio was 2.23 (95% CI 1.67-2.99, P < .001). For disease-free survival, the pooled hazard ratio was 2.24 (95% CI 1.69-2.96, P < .001). The results suggested that high expression of MIF was significantly related to poor overall survival and disease-free survival in cancer patients.ConclusionMIF expression could be a valuable prognostic factor in cancer patients.
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