• Huanjia Gao, Shiyu Liu, Hairong Cai, Dongjie Chen, Xue Fu, Shuai Zhao, and Bojun Chen.
• The Second Clinical Medical School, Guangzhou University of Chinese Medicine.
• Medicine (Baltimore). 2020 Aug 7; 99 (32): e21589e21589.

BackgroundCoronary heart disease (CHD) is the leading cause of morbidity and mortality worldwide. Guipi Decoction (GPD) is a classical traditional Chinese medication used to treat CHD. However, systematic review and meta-analysis regarding its efficacy and safety has not been systematically evaluated. The objective of this protocol is to determine the efficacy and safety of GPD in the treatment of CHD.MethodsRandomized controlled trials evaluating the effectiveness and safety of GPD in the treatment of CHD will be retrieved from 8 electronic databases, including PubMed, EMBASE, Cochrane Library, Web of science, China National Knowledge Infrastructure Database, VIP Database, Wanfang Database and China Biology Medicine Database. Study selection, data collection, risk of bias assessment, and evaluation of the quality of evidence will be performed in order. Data will be analyzed by RevMan V.5.3.5 software.ResultsThis study will evaluate the efficacy and safety of GPD in the treatment of CHD.ConclusionThis systematic review will provide evidence for determining whether or not GPD is an effective and safe intervention for CHD.Prospero Registration NumberPROSPERO CRD 42020156420.

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