• Medicine · Aug 2020

    Effect of butylphthalide on new cerebral microbleeds in patients with acute ischemic stroke.

    • Yunlong Ding, Zhiqun Gu, Tingting Zhai, Wenjuan Wang, Yanrong Zhang, Can Wei, Yan Liu, and Jiali Niu.
    • Department of Neurology, Jingjiang People's Hospital, the Seventh Affiliated Hospital of Yangzhou University, Jiangsu, China.
    • Medicine (Baltimore). 2020 Aug 7; 99 (32): e21594.

    BackgroundTo evaluate the effect of dl-3-N-butylphthalide (NBP) on new cerebral microbleeds (CMBs) in patients with acute ischemic stroke (AIS).MethodsWe will prospectively enroll patients with AIS admitted to the stroke center of Jingjiang People's Hospital. Qualified participants will be randomly assigned to either the NBP group (NBP injection) or the control group (NBP injection placebo) in a ratio of 1:1. Patients will complete the brain magnetic resonance imaging within 48 hours and 14 days after stroke onset to observe the CMBs through susceptibility weighted imaging, and evaluate whether the use of NBP will affect the new CMBs in AIS patients. SPSS 20.0 will be used for statistical analyses.ResultWe will provide practical and targeted results assessing the safety of NBP for AIS patients, to provide reference for clinical use of NBP.ConclusionThe stronger evidence about the effect of NBP on new CMBs in AIS patients will be provided for clinicians.

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