• Jorge Martínez-Del Río, Jesús Piqueras-Flores, Patricia Nieto-Sandoval Martín de la Sierra, Martín Negreira-Caamaño, Daniel Águila-Gordo, Cristina Mateo-Gómez, Daniel Salas-Bravo, and Marta Rodríguez-Martínez.
• Servicio de Cardiología, Hospital General Universitario de Ciudad Real, Ciudad Real, España. Electronic address: jorgemartinezmedi@hotmail.com.
• Med Clin (Barc). 2020 Dec 11; 155 (11): 473481473-481.

IntroductionHypertension has been associated with worse outcomes in patients with COVID-19 infection, so concerns have been raised about the possibility that inhibitors of the renin-angiotensin system (RAS) could influence the prognosis of these patients.MethodsThis is an observational study of 921 consecutive patients admitted with COVID-19 respiratory infection to Hospital General Universitario Ciudad Real from March 1 to April 30, 2020. Following data were collected including patient demographic information, medical history, clinical characteristics, laboratory data, therapeutic interventions during the hospitalization and clinical outcomes.ResultsThe mean age was 78years, and 59.2% of patients had a history of hypertension. Patients with previous treatment with RAS inhibitor (42.4%) showed lower risk of the primary composite endpoint (mortality or need for invasive mechanical ventilation). Treatment with RAS inhibitor (both outpatient treatment and during hospitalization) had neither effect on mortality nor need for invasive ventilation. There were no differences in time-to-event analysis between groups.ConclusionsRAS inhibitor treatment prior to admission in patients with COVID-19 respiratory infection was associated with lower risk of the primary composite endpoint and did not show neither impact on mortality nor need for invasive mechanical ventilation, even if these drugs were prescribed during hospitalization.Copyright © 2020 Elsevier España, S.L.U. All rights reserved.

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