[Analgesic efficacy of topical lidocaine for vaso-occlusive

Arch Pediatr · Jul 2013

Case Reports

[Analgesic efficacy of topical lidocaine for vaso-occlusive crisis in children with sickle cell disease].

Pain associated with vaso-occlusive crisis is the main cause of hospitalization in children with sickle cell disease. Recent studies have suggested that pain might have a neuropathic component. ⋯ This study reports the efficacy and safety of such treatment in 6 patients with sickle cell disease, aged 6-18 years, who had been hospitalized for vaso-occlusive crisis after failure of the standard analgesic treatment. These data have led to setting up a confirmatory phase II trial, which is currently underway.

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- J Rasolofo, M Poncelet, V Rousseau, and P Marec-Berard.
- Institut d'hématologie et d'oncologie pédiatrique (IHOP), CHU de Lyon, 28, rue Laennec, 69373 Lyon cedex 08, France.
- Arch Pediatr. 2013 Jul 1; 20 (7): 762-7.
AbstractPain associated with vaso-occlusive crisis is the main cause of hospitalization in children with sickle cell disease. Recent studies have suggested that pain might have a neuropathic component. Lidocaine patches are commonly prescribed as a topical analgesic in adult neuropathic pain. This study reports the efficacy and safety of such treatment in 6 patients with sickle cell disease, aged 6-18 years, who had been hospitalized for vaso-occlusive crisis after failure of the standard analgesic treatment. These data have led to setting up a confirmatory phase II trial, which is currently underway. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

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[Analgesic efficacy of topical lidocaine for vaso-occlusive crisis in children with sickle cell disease].

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