• Mehmet Sercan Erturk, Bulent Cekic, and Mehmet Celik.
• Department of Endocrinology and Metabolism, University of Health Sciences, Antalya Training and Research Hospital, Antalya, Turkey.
• J Coll Physicians Surg Pak. 2020 Jul 1; 30 (7): 694-700.

Objective To explore the alterations of neutrophil-to-lymphocyte ratio (NLR) as a systemic inflammatory marker after microwave ablation for benign thyroid nodules.   Study Design: A descriptive study.Place And Duration Of StudyDepartment of Radiology, Antalya Training and Research Hospital, from December 2018 to June 2019.MethodologyDemographic data of the patients, ultrasonographic features of the nodules, thyroid function tests of the patients, leukocyte, neutrophil, lymphocyte values, and thyroid nodule volumes of the patients before and after the procedure were recorded. NLR and volume reduction ratio (VRR %) of 35 patients with thyroid nodules were compared before and after microwave ablation therapy of the thyroid nodules.ResultsThe nodule volume decreased from 23.89 ±15.44 cc to 11.57 ±8.65 cc at two months and to 7.79 ±5.74 cc at six months. The VRR% increased from 38.65 ±16.82 to 63.16 ±14.19 at three months and to 68.29 ±11.80 at six months. The mean value of NLR decreased from 2.28 ±0.86 to 1.78 ±0.54. ROC curve analysis suggested that the optimum pre-NLR cut-off point for 50% VRR success was 2.50 with the specifity and sensitivity of 0.67 and 0.50.ConclusionAfter ultrasound-guided microwave ablation of benign thyroid module, VRR percentage increased significantly, while the inflammatory marker NLR value decreased. Key Words: Biomarker, Inflammation, Microwaves, Neutrophil-to-lymphocyte ratio, Thyroid nodule.

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