• Serkan Tursun, Aysegul Alpcan, Ergur Ayca Torel AT Department of Pediatrics Endocrinology, Faculty of Medicine, Ufuk University, Turkey., Irfan Karahan, Salim Neselioglu, and Ozcan Erel.
• Department of Pediatrics, Faculty of Medicine, Kirikkale University, Turkey.
• J Coll Physicians Surg Pak. 2020 Jul 1; 30 (7): 726-729.

ObjectiveTo determine the effects of subclinical hypothyroidism on oxidative stress in children.Study DesignA cross-sectional study.Place And Duration Of StudyDepartment of Paediatrics, Paediatric Endocrinology, and General Outpatient Clinics, Kirikkale University, School of Medicine, from May 2017 to October 2018.MethodologyThis study included 92 subjects aged between 2 and 18 years. The subjects were divided into two groups. Forty-seven children with subclinical hypothyroidism and 45 healthy controls were evaluated. In order to evaluate oxidative damage, native thiol, total thiol, disulfides, their ratios, and ischemia-modified albumin (IMA) levels were compared between the two groups. The relationship between TSH and IMA levels was assessed.ResultsAge and gender were not significantly different in the two groups. Native thiol, total thiol, disulfides and their ratios were similar in the two groups. Ischemia-modified albumin levels were significantly higher in the patient group than the controls (p<0.001). There was no correlation between TSH and IMA levels in the patient group (r=0.069 p=0.645).ConclusionSubclinical hypothyroidism may be related to the impairment of IMA, and have a neutral effect on thiol/disulfide balance. Further research is needed to explain the effects of oxidative stress in subclinical hypothyroidism. Key Words: Subclinical hypothyroidism, Childhood, Oxidative stress.

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