• Medicine · Apr 2020

    Comparative Study Observational Study

    Sex differences in uric acid and NT-pro BNP assessments during coronary severity.

    • Guofeng Guo, Zhaoqi Huang, Shixiang Wang, and Ximing Chen.
    • Department of Cardiology, the third affiliated Hospital of Guangzhou Medical University, Guangdong Province, China.
    • Medicine (Baltimore). 2020 Apr 1; 99 (15): e19653e19653.

    AbstractTo investigate the correlation between uric acid (UA) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels and coronary artery severity in acute coronary syndrome patients of different sexes.A total of 134 patients with acute coronary syndrome (ACS) were investigated. According to sex, there were 96 cases in male group and 38 cases in female group. According to the number of diseased vessels, the degree of coronary artery lesion was determined and divided into negative group (n = 21), single vessel lesion group (n = 43), double vessel lesion group (n = 38), and 3 vessel lesion group (n = 32).Univariate analysis showed that UA, NT-proBNP was correlated with the severity of ACS (P < .05). UA was an independent risk factor for the severity of coronary artery disease in female group (P < .05), but not in male group (P > .05). There was no significant correlation between NT-proBNP and severity of coronary artery disease in different sex (P > .05).UA was significantly correlated with the severity of coronary heart disease, especially in women, but not in men. The level of NT-proBNP was positively correlated with the severity of coronary artery, but no significant difference was found in different sexes.

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