• Maria Lucia Zarvos Varellis, Marcela Leticia Leal Gonçalves, Vanessa Christina Santos Pavesi, HorlianaAnna Carolina Ratto TempestiniACRT, Daniela de Fátima Teixeira da Silva, Lara Jansiski Motta, Valdomiro F Barbosa Filho, Cícero Dayves Silva Bezerra, Felipe Gonçalves da Silva, Sandra Kalil Bussadori, and Alessandro M Deana.
• Postgraduate Program in Biophotonics Applied to Health Sciences, University Nove de Julho (UNINOVE), Rua Vergueiro, Liberdade, São Paulo, Brazil.
• Medicine (Baltimore). 2020 Apr 1; 99 (16): e19583e19583.

IntroductionHypertension (systemic arterial hypertension [SAH]) is a systemic condition that affects about 30% of the world population, according to data from the World Health Organization (WHO). Drugs used to control this disease have the potential to induce xerostomia, an oral condition in which the decrease of the salivary flow is observed and whose presence leads to the increase of the index of caries, periodontal disease, loss of the teeth, dysgeusia, difficulty of mastication, dysphagia, bad breath and oral burning and impairment of prothesis installed in the buccal cavity, including retention of removable and total dentures.MethodsThis is a randomized, placebo-controlled, blind clinical protocol that aims to analyze the impact of phobiomodulation (PBM) on salivary glands of patients with antihypertensive drug induced xerostomia. Patients will be divided into 2 groups: G1: older adults with xerostomia induced by antihypertensive drugs and treatment with PBM (n = 30); G2: placebo PBM (n = 30). The irradiation will be made using a diode laser emitting at 808 nm with 100 mW and 40 seconds of exposure per site at the salivary glands. Twenty sites will be irradiated weekly for 4 weeks. Non-stimulated and stimulated salivary flow will be analyzed before and after the treatment.ResultsThis protocol will determine the effectiveness of photodynamic therapy regarding the reduction of xerostomia in older adults using antihypertensive drugs.ConclusionThis protocol will determine the effectiveness of photodynamic therapy regarding the reduction of xerostomia in older adults using antihypertensive drugs.Trial RegistrationClinicaltrials.gov - NCT03632096.

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