• Medicine · Aug 2020

    Meta Analysis

    Association between PTGER4 polymorphisms and inflammatory bowel disease risk in Caucasian: A meta-analysis.

    • Peng-Bo Wu, Rao Qian, Chai Hong, Yi-Tian Guo, Yuan-Jie Yu, Guo Zhang, and Shi-Yun Tan.
    • Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, Hubei.
    • Medicine (Baltimore). 2020 Aug 21; 99 (34): e19756e19756.

    BackgroundThe results from previous studies on association between prostaglandin E receptor 4 (PTGER4) polymorphisms and inflammatory bowel disease (IBD) risk in Caucasian were conflict. The present study aimed to investigate the genetic association by conducting a meta-analysis.MethodsSystematic literature search was conducted through Wiley Online Library, Chinese National Knowledge Infrastructure (CNKI), and PubMed databases. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to investigate the associations between rs4613763 T/C, 17234657T/G polymorphisms, and IBD risk in Caucasian.ResultsTwenty case-control studies consisting of 18,495 Crohn disease (CD) patients and 4203 ulcerative colitis (UC) patients, as well as 26,063 controls were included in this meta-analysis. The rs4613763T/C polymorphism had obvious influence on CD, UC risk in Caucasian. However, rs17234657T/G polymorphism had obvious influence on CD but not UC in Caucasian.ConclusionThis meta-analysis suggested that both the rs4613763 T/C, rs17234657T/G polymorphisms had obvious influence on risk of CD in Caucasian. In addition, rs4613763 T/C, polymorphism had obvious influence on risk of UC in Caucasian.

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