• Chongyao Jin, Jiali Pu, Zhijian Zhou, Xia Chen, Jimin Wu, and Baorong Zhang.
• Department of Neurology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou.
• Medicine (Baltimore). 2020 Aug 21; 99 (34): e21757.

RationaleCerebral venous thrombosis (CVT) is a rare cerebrovascular condition, which mainly manifests as headaches, seizures, and focal neurological deficits. JAK2 mutation in myeloproliferative diseases increases the risk of CVT.Patient ConcernsThis 40-year-old woman suffered from rapidly progressive cognitive impairment and limb weakness. Her symptoms worsened while being treated with mannitol with the diagnose of cerebral hemorrhage.DiagnosisThe patient was diagnosed with CVT and multiple intracranial hemorrhage caused by JAK2 V617F mutation-positive primary myelofibrosis by neuroimage and whole-exome sequencing.InterventionShe received low-molecular-weight heparin sodium 3800 IU twice a day followed by oral anticoagulant therapy.OutcomesThe patient showed full recovery from limb weakness and in the follow-up period she noticed no change in her memory.LessonsClinicians should be aware of the possibility of the JAK2 V617F mutation in CVT patients without known causes or risk factors.

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