• Hao-Yuan Tsai, Yen-Wen Wu, Wei-Kung Tseng, Hsin-Bang Leu, Wei-Hsian Yin, Tsung-Hsien Lin, Kuan-Cheng Chang, Ji-Hung Wang, Hung-I Yeh, Chau-Chung Wu, Jaw-Wen Chen, and National Taiwan Biosignature Research Investigators.
• Cardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
• J Formos Med Assoc. 2021 Jan 1; 120 (1 Pt 3): 728-736.

BackgroundFatty-acid binding protein-4 (FABP4) has been associated with the metabolic syndrome, diabetes mellitus, atherosclerosis, incident heart failure, and the prognosis of coronary heart disease (CHD). However, recent studies have not reported a significant correlation between FABP4 and cardiovascular (CV) mortality in high-risk patients or those with documented CHD. The present study aimed to evaluate the association between FABP4 and the prognosis in a cohort of patients with CHD who received coronary interventions.MethodsSerum FABP4 levels were measured in 973 patients after a successful intervention for CHD, who were then prospectively followed for 30 months.ResultDuring this period, 223 patients experienced composite CV outcomes (22.92%), defined as cardiovascular/cerebrovascular death, nonfatal myocardial infarction (MI), nonfatal stroke, hospitalization for refractory or unstable angina, hospitalization for heart failure, and peripheral artery occlusive disease. Kaplan-Meier curves showed a significant association between FABP4 levels at baseline (categorized in tertiles) and composite CV outcomes during follow-up (log-rank test, p < 0.003). The patients with the highest tertile of baseline FABP4 had an increased risk of composite CV outcomes (hazard ratio (HR) 1.662; 95% confidence interval (CI), 1.2-2.302; p = 0.0022), which remained significant after multivariate adjustments for traditional risk factors and hs-CRP (HR 1.596; 95% CI, 1.088-2.342; p = 0.0168). In contrast, FABP4 failed to show a significant association with cardiovascular/cerebrovascular death, nonfatal MI, or nonfatal stroke after multivariate adjustments (HR, 1.594; 95% CI, 0.651-3.904, p = 0.3073).ConclusionIn conclusion, circulating FABP4 is an independent prognostic predictor for the composite cardiovascular events in the patients with stable CHD after coronary interventions.Copyright © 2020 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.

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