• Manami Oda, Anthony Kalloo, Kazuhiro Mizukami, Kazunari Murakami, and Akira Sawa.
• Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, USA.
• Intern. Med. 2021 Feb 1; 60 (3): 327-335.

AbstractBarrett's esophagus (BE) is a precancerous disease that can lead to esophageal adenocarcinoma (EAC). Recently, the incidence of EAC arising from BE has been increasing, and EAC has now become a threat in many countries. However, there are many gaps among the various countries in terms of definitions and concepts and these gaps prevent discussing BE on the same footing. In order to eradicate BE, it is a global necessity to fill in these remaining gaps. We focused on the gaps and reviewed recent evidence and trends as well as the background of gaps between the US and Japan as two of the leading countries in the field of medical research. We also review the rapid advances in endoscopic techniques in relation to both diagnosis and therapy that are considered to be useful to eliminate the gaps between countries.

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