• Internal medicine · Feb 2021

    Case Reports

    Multiple Malignant Lymphomas of the Bile Duct Developing after Spontaneous Regression of an Autoimmune Pancreatitis-like Mass.

    • Koushiro Ohtsubo, Kaname Yamashita, Naohiro Yanagimura, Chiaki Suzuki, Azusa Tanimoto, Akihiro Nishiyama, Shinji Takeuchi, Noriko Iwaki, Mitsuhiro Kawano, Akira Izumozaki, Dai Inoue, Toshifumi Gabata, Hiroko Ikeda, Michio Watanabe, and Seiji Yano.
    • Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Japan.
    • Intern. Med. 2021 Feb 1; 60 (3): 409-415.

    AbstractWe herein report a 67-year-old woman with malignant lymphomas of the bile duct that developed after regression of a pancreatic head mass. Computed tomography suggested the mass was pancreatic head cancer. Endoscopic ultrasonography showed a low-echoic mass with hyperechoic strands resembling autoimmune pancreatitis. Her serum IgG4 concentration was elevated to 674 mg/dL. After the pancreatic head mass spontaneously diminished, three masses were detected in the common bile duct. A biopsy of the major papilla revealed high-grade B-cell lymphoma with MYC, BCL2 and/or BCL6 rearrangement. Systemic chemotherapy with rituximab plus etoposide, prednisolone, vincristine, cyclophosphamide and doxorubicin resulted in complete remission.

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