• XiaoGuang Lin, XueLing Zhang, QinQin Liu, PanWen Zhao, JianGuo Zhong, PingLei Pan, GenDi Wang, and ZhongQuan Yi.
• aDepartment of Neurology, Affiliated Suqian Hospital of Xuzhou Medical University, Suqian bDepartment of Central Laboratory cDepartment of Neurology, Affiliated Yancheng School of Clinical Medicine of Nanjing Medical University, P.R. China.
• Medicine (Baltimore). 2020 Aug 14; 99 (33): e21773.

BackgroundMultiple sclerosis (MS) is an immune-mediated demyelinating disease of the central nervous system (CNS). Recently, numerous studies have shown that MS disrupts a number of social cognitive abilities, including empathy, theory of mind (ToM), and facial emotion recognition. In contrast to well-documented deficits in the core social cognitive domains of ToM and facial emotion recognition, it is not clear the broad and specific subcomponents of empathy processing affected. In addition, the specific subcomponents of ToM affected in MS are also unclear. The aim of this study is to conduct a systematic review and meta-analysis to characterize the performance of empathy and ToM in MS.MethodsA systematic literature search will be performed for eligible studies published up to July 1st, 2020 in 3 international databases (PubMed, Web of Science, and Embase). The work such as article retrieval, screen, quality evaluation, data collection will be conducted by 2 independent researchers. Meta-analysis will be performed using Stata 15.0 software.ResultsThe results of this study will be published in a peer-reviewed journal.ConclusionsThis meta-analysis will provide a high-quality synthesis from existing evidence for the performance of empathy and ToM in MS.Prospero Registration NumberINPLASY202070029.

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