• Neelum Zaka, Naheed Gul, Nadia Ishfaq, Lubna Meraj, and Mehwish Rafique.
• Department of Medicine, Shifa College of Medicine, Shifa International Hospital, Islamabad, Pakistan.
• J Coll Physicians Surg Pak. 2020 Aug 1; 30 (8): 822-827.

ObjectiveTo determine the association of hypertension with Non-HDL Cholesterol (Non-HDL.C) among patients with type 2 diabetes mellitus.Study DesignDescriptive study.Place And Duration Of Study Shifa Foundation Community Health Centre, Shifa International Hospital, Islamabad, from January to December 2019.Methodology This study comprised of 214 patients with type 2 diabetes. Detailed history, examination, anthropometric measurements, fasting lipid profiles and blood glucose levels were recorded for all patients. Non-HDL.C was determined in all patients by subtracting HDL Cholesterol (HDL.C) from total Cholesterol (Total.C). Association of hypertension with Non-HDL.C was analysed using Chi-square Fisher Exact test for qualitative data and post-stratification t-test for quantitative data. Correlation of rising levels of Non-HDL.C with Total.C, LDL.C, Triglycerides, HDL.C and fasting blood sugar was analysed using ANOVA. SPSS version 23 was used for statistical analysis.ResultsNon-HDL.C was raised in 169 (78.97%) patients with type 2 diabetes. However, there was no significant difference in the mean Non-HDL.C among patients with hypertension and without hypertension (156.35 +38.52 mg/dl versus 156.81 +45.82 mg/dl; p = 0.936). Furthermore, there was no significant difference in the Total.C, LDL.C, Triglycerides and the number of patients with raised Non-HDL.C among both groups. Increasing values of Non-HDL.C correlated significantly to Total.C, LDL.C and Triglycerides (p <0.001).ConclusionHypertension had no significant association with Non-HDL.C in patients with type 2 diabetes. However, the raised level of Non-HDL.C in majority of type 2 diabetic patients in addition to significant correlation with Total.C, LDL.C and Triglycerides necessitates its screening irrespective of the blood pressure status. Key Words: Non-HDL cholesterol, Dyslipidemia, Diabetes, Hypertension.

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