• Muhammad Abrar Barakzai, Muhammad Akhtar, Nasir Ali Afsar, Abdulaziz Ajlan M Alsalloom, Junaid Kashir, and Turki O Al Hussain.
• Department of Pathology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
• J Coll Physicians Surg Pak. 2020 Aug 1; 30 (8): 857-862.

Objective To determine and compare the distribution of oestrogen and progesterone receptors (ER and PR) expression between normal kidneys and chronic pyelonephritis.Study DesignComparative-descriptive study.Place And Duration Of StudyKing Faisal Specialist Hospital and Research Centre, and Alfaisal University, Riyadh, Saudi Arabia, between January 2017 and December 2018.  Methodology: Renal specimens, including 41 chronic pyelonephritis, and 21 healthy specimens were examined. ER/PR expression was determined immunohistochemically, termed focal if <50% of nuclei stained positively, and diffuse when >50%. The intensity of staining was labelled weak (pale), moderate or strong.ResultsMajority of samples showed presence of diffuse ER (82.9% diseased; 71.4% healthy) and focal PR (53.7% diseased; 76.2% healthy), mostly with strong intensity. ER and PR distribution whether focal or diffuse, correlated with each other in 41.9%. All proportions comparisons showed p values greater than 0.05.ConclusionThere was a trend of diffuse renal stromal expression of ER and PR in chronic pyelonephritis as compared to healthy specimens. However, the difference did not reach statistical significance. Key Words: Oestrogen receptor, Progesterone receptor, Chronic pyelonephritis, Renal cancer, Renal stroma.

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