• Nutrition · Apr 2014

    Randomized Controlled Trial

    Brazilian nut consumption by healthy volunteers improves inflammatory parameters.

    • Elisângela Colpo, Carlos Dalton D A Vilanova, Luiz Gustavo B Reetz, Marta M M F Duarte, Iria Luiza G Farias, Daiane F Meinerz, Douglas O C Mariano, Raquel G Vendrusculo, Aline A Boligon, Cristiane L Dalla Corte, Roger Wagner, Margareth L Athayde, and João Batista T da Rocha.
    • Department of Biochemistry and Molecular Biology, Natural and Exact Sciences Centers, Federal University of Santa Maria, Santa Maria, Brazil; Department of Nutrition, Center Franciscan University, Santa Maria, Brazil.
    • Nutrition. 2014 Apr 1;30(4):459-65.

    ObjectiveThe aim of this study was to investigate the effect of a single dose of Brazil nuts on the inflammatory markers of healthy individuals.MethodA randomized crossover study was conducted with 10 healthy individuals (mean age 24.7 ± 3.4 y). Each individual was tested four times regarding intake of different portions of Brazil nuts: 0, 5, 20 and 50 g. At each testing period, peripheral blood was collected before and at 1, 3, 6, 9, 24, and 48 h after intake of nuts, as well as at 5 and 30 d after intake of various Brazil nut portions. Blood samples were tested for high-sensitivity to C-reactive protein, interleukin (IL)-1, IL-6, IL-10, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ, aspartate and alanine aminotransferases, albumin, total protein, alkaline phosphatase, gamma-glutamyltransferase, urea, and creatinine.ResultsConsumption of nuts did not affect biochemical parameters for liver and kidney function, indicating absence of hepatic and renal toxicity. A single intake of Brazil nuts (20 or 50 g) caused a significant decrease in serum IL-1, IL-6, TNF-α, and IFN-γ levels (P < 0.05), whereas serum levels of IL-10 were significantly increased (P < 0.05).ConclusionThe results indicate a long-term decrease in inflammatory markers after a single intake of large portions of Brazil nuts in healthy volunteers. Therefore, the long-term effect of regular Brazil nut consumption on inflammatory markers should be better investigated.Copyright © 2014 Elsevier Inc. All rights reserved.

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