• Liuwei Chen and Quanbin Zhang.
• Department of Neurosurgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
• World Neurosurg. 2021 Jan 1; 145: e32-e37.

BackgroundThe purpose of this study was to explore the relationship between mean platelet volume (MPV) and aneurysm recurrence in aneurysmal subarachnoid hemorrhage (aSAH) patients who received endovascular treatment for intracranial aneurysms.MethodsData were collected and analyzed from 204 aneurysms in 187 aSAH patients who received endovascular treatment at our institution between January 2014 and January 2019. All aneurysms were divided into 2 groups based on aneurysm recurrence. Univariate and multivariable analyses were performed to investigate whether MPV was an independent predictor of aneurysm recurrence. The receiver operating characteristic (ROC) curve and area under the curve (AUC) were determined.ResultsA total of 42 (20.6%) aneurysms recurred. Recurrent aneurysms had a lower rate of complete obliteration (P = 0.002) and lower MPV values on admission (P < 0.001) than nonrecurrent aneurysms. The multivariable analysis showed that the Raymond-Roy classification (odds ratio [OR]: 3.217, 95% confidence interval [CI]: 1.308-7.913, P = 0.011) and MPV (OR: 0.247, 95% CI: 0.151-0.402, P < 0.001) was significantly associated with aneurysm recurrence. The ROC curve analysis determined that MPV could predict aneurysm recurrence with an AUC of 0.846 (95% CI: 0.788-0.892, P < 0.001). An MPV ≤9.9 fL could predict aneurysm recurrence with a sensitivity of 80.95% and a specificity of 79.63%.ConclusionsA low perioperative MPV may be associated with aneurysm recurrence in aSAH patients who receive endovascular treatment for intracranial aneurysms. Therefore, MPV can be used in clinical settings to screen for patients at high risk for aneurysm recurrence.Copyright © 2020 Elsevier Inc. All rights reserved.

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