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Ann Fr Anesth Reanim · Jan 1993
Case Reports[Tetraplegia after colonoscopy: benzodiazepine withdrawal syndrome induced by flumazenil?].
- J C Sleth and O Duhamel.
- Département d'Anesthésie-Réanimation, CHG de Béziers.
- Ann Fr Anesth Reanim. 1993 Jan 1; 12 (4): 434-6.
AbstractA case is reported of a 68-year-old female patient who developed a flaccid tetraplegia on recovering from a colonoscopy, carried out under general anaesthesia (3 mg of midazolam, 20 mg of etomidate). During the preanaesthetic visit, she omitted to report a 15-year-addiction to lorazepam 2.5 mg every night. At the end of the procedure, 0.2 mg of flumazenil were injected. Recovery was immediate but followed by neurological signs associating general weakness, paraesthesia and tetraplegia. These symptoms discontinued spontaneously two hours later. She was discharged the same day but complained of myalgia and paraesthesia for a week. The physiopathology of this accident is unknown. The differential diagnosis and the influence of flumazenil on benzodiazepine withdrawal are discussed.
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