• Song-Yi Park, Neal D Freedman, Christopher A Haiman, Loïc Le Marchand, Lynne R Wilkens, and Veronica Wendy Setiawan.
• From University of Hawai'i Cancer Center, Honolulu, Hawaii; National Cancer Institute, Bethesda, Maryland; and Keck School of Medicine of the University of Southern California, Los Angeles, California.
• Ann. Intern. Med. 2017 Aug 15; 167 (4): 228235228-235.

BackgroundCoffee consumption has been associated with reduced risk for death in prospective cohort studies; however, data in nonwhites are sparse.ObjectiveTo examine the association of coffee consumption with risk for total and cause-specific death.DesignThe MEC (Multiethnic Cohort), a prospective population-based cohort study established between 1993 and 1996.SettingHawaii and Los Angeles, California.Participants185 855 African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites aged 45 to 75 years at recruitment.MeasurementsOutcomes were total and cause-specific mortality between 1993 and 2012. Coffee intake was assessed at baseline by means of a validated food-frequency questionnaire.Results58 397 participants died during 3 195 484 person-years of follow-up (average follow-up, 16.2 years). Compared with drinking no coffee, coffee consumption was associated with lower total mortality after adjustment for smoking and other potential confounders (1 cup per day: hazard ratio [HR], 0.88 [95% CI, 0.85 to 0.91]; 2 to 3 cups per day: HR, 0.82 [CI, 0.79 to 0.86]; ≥4 cups per day: HR, 0.82 [CI, 0.78 to 0.87]; P for trend < 0.001). Trends were similar between caffeinated and decaffeinated coffee. Significant inverse associations were observed in 4 ethnic groups; the association in Native Hawaiians did not reach statistical significance. Inverse associations were also seen in never-smokers, younger participants (<55 years), and those who had not previously reported a chronic disease. Among examined end points, inverse associations were observed for deaths due to heart disease, cancer, respiratory disease, stroke, diabetes, and kidney disease.LimitationUnmeasured confounding and measurement error, although sensitivity analysis suggested that neither was likely to affect results.ConclusionHigher consumption of coffee was associated with lower risk for death in African Americans, Japanese Americans, Latinos, and whites.Primary Funding SourceNational Cancer Institute.

30 keywords...

hide…