• RiveraEduardo A TrujilloEATGeorge Washington University School of Medicine and Health Sciences, Washington, DC., Anita K Patel, Qing Zeng-Treitler, James M Chamberlain, James E Bost, Julia A Heneghan, Hiroki Morizono, and Murray M Pollack.
• George Washington University School of Medicine and Health Sciences, Washington, DC.
• Pediatr Crit Care Me. 2021 Jan 1; 22 (1): e19e32e19-e32.

ObjectivesTo assess severity of illness trajectories described by the Criticality Index for survivors and deaths in five patient groups defined by the sequence of patient care in ICU and routine patient care locations.DesignThe Criticality Index developed using a calibrated, deep neural network, measures severity of illness using physiology, therapies, and therapeutic intensity. Criticality Index values in sequential 6-hour time periods described severity trajectories.SettingHospitals with pediatric inpatient and ICU care.PatientsPediatric patients never cared for in an ICU (n = 20,091), patients only cared for in the ICU (n = 2,096) and patients cared for in both ICU and non-ICU care locations (n = 17,023) from 2009 to 2016 Health Facts database (Cerner Corporation, Kansas City, MO).InterventionsNone.Measurements And Main ResultsCriticality Index values were consistent with clinical experience. The median (25-75th percentile) ICU Criticality Index values (0.878 [0.696-0.966]) were more than 80-fold higher than the non-ICU values (0.010 [0.002-0.099]). Non-ICU Criticality Index values for patients transferred to the ICU were 40-fold higher than those never transferred to the ICU (0.164 vs 0.004). The median for ICU deaths was higher than ICU survivors (0.983 vs 0.875) (p < 0.001). The severity trajectories for the five groups met expectations based on clinical experience. Survivors had increasing Criticality Index values in non-ICU locations prior to ICU admission, decreasing Criticality Index values in the ICU, and decreasing Criticality Index values until hospital discharge. Deaths had higher Criticality Index values than survivors, steeper increases prior to the ICU, and worsening values in the ICU. Deaths had a variable course, especially those who died in non-ICU care locations, consistent with deaths associated with both active therapies and withdrawals/limitations of care.ConclusionsSeverity trajectories measured by the Criticality Index showed strong validity, reflecting the expected clinical course for five diverse patient groups.Copyright © 2020 by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

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