• Sydney M Finegold, Paula H Summanen, Karen Corbett, Julia Downes, Susanne M Henning, and Zhaoping Li.
• Infectious Diseases Section, VA Medical Center West Los Angeles, Los Angeles, California, USA; Research Service, VA Medical Center West Los Angeles, Los Angeles, California, USA; Department of Microbiology, Immunology and Molecular Genetics, UCLA School of Medicine, Los Angeles, California, USA; Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA. Electronic address: sidfinegold@gmail.com.
• Nutrition. 2014 Oct 1;30(10):1210-2.

ObjectiveTo determine the possible utility of pomegranate extract in the management or prevention of Clostridium difficile infections or colonization.MethodThe activity of pomegranate was tested against 29 clinical C. difficile isolates using the Clinical and Laboratory Standards Institute-approved agar dilution technique. Total phenolics content of the pomegranate extract was determined by Folin-Ciocalteau colorimetric method and final concentrations of 6.25 to 400 μg/mL gallic acid equivalent were achieved in the agar.ResultsAll strains had MICs at 12.5 to 25 mg/mL gallic acid equivalent range. Our results suggest antimicrobial in vitro activity for pomegranate extract against toxigenic C. difficile.ConclusionPomegranate extract may be a useful contributor to the management and prevention of C. difficile disease or colonization.Copyright © 2014 Elsevier Inc. All rights reserved.

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