• Chest · Jan 2021

    Case Reports

    Etoposide as Salvage Therapy for Cytokine Storm due to COVID-19.

    • Maulin Patel, Eduardo Dominguez, Daniel Sacher, Parag Desai, Ashwin Chandar, Michael Bromberg, Roberto Caricchio, Gerard J Criner, and Temple University COVID-19 Research Group.
    • Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA. Electronic address: maulin.patel@tuhs.temple.edu.
    • Chest. 2021 Jan 1; 159 (1): e7-e11.

    AbstractCoronavirus disease 2019 (COVID-19) has resulted in significant morbidity and mortality because of a lack of effective therapies. Therapeutic strategies under investigation target the overactive cytokine response with anti-cytokine or immunomodulators therapies. We present a unique case of severe cytokine storm resistant to multiple anti-cytokine therapies, but eventually responsive to etoposide. Thus, etoposide may have a role as salvage therapy in treatment of cytokine storm in COVID-19. To our knowledge, this is the first reported case of use of etoposide in COVID-19.Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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