• J Clin Anesth · Feb 2012

    Review Meta Analysis Comparative Study

    Meta-analysis of the effect of central neuraxial regional anesthesia compared with general anesthesia on postoperative natural killer T lymphocyte function.

    • Ian Conrick-Martin, Malcolm R Kell, and Donal J Buggy.
    • Department of Anaesthesia, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland. iancm25@hotmail.com
    • J Clin Anesth. 2012 Feb 1;24(1):3-7.

    Study ObjectiveTo compare the effect of central neuraxial (spinal or epidural) anesthesia with general anesthesia on postoperative natural killer (NK) T lymphocyte function.DesignMeta-analysis.SettingUniversity-affiliated hospital.MeasurementsA systematic search of the medical literature from 1966 to 2009 yielded 5 eligible studies with a total of 184 patients who received neuraxial blockade. Natural killer T lymphocyte function was studied.Main ResultsThere was significant heterogeneity between the studies [I(2) = 94.4% (95% CI= 90.3-96.2%)]. Overall fixed-effect odds ratio was 0.86 (0.66-1.14, P = 0.25). The random-effect odds ratio was 1.13 (0.26-4.92, P = 0.79).ConclusionAnesthetic technique does not appear to significantly affect postoperative NK T lymphocyte function. Given the heterogeneity observed, further clinical studies in cancer patients of the effect of anesthetic technique on immune function in general, and NK T lymphocyte function in particular, are needed.Copyright © 2012 Elsevier Inc. All rights reserved.

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