• Dongjie Chen, Chenyue Li, Hairong Cai, Jieqin Zhuang, Yonglian Huang, Xiaohong Peng, Shaoping Li, Yaxiu Huang, Ping Wang, Yajie Luo, and Zhenye Zhan.
• Department of Critical Care Medicine, Beijing University of Chinese Medicine Shenzhen Hospital.
• Medicine (Baltimore). 2020 Feb 1; 99 (9): e19309.

BackgroundH-type hypertension is a kind of cardiovascular disease that threatens human life and health seriously. Banxia Baizhu Tianma Tang (BBTT) has been used widely for H-type hypertension while its effective evidence is not clear. Hence, we provide a systematic review protocol to evaluate the efficacy and safety of BBTT in the treatment of H-type hypertension.MethodsNine databases including Cochrane Library, PubMed, EMBASE, WOS, Medline, CNKI, WangFang, CBM, and VIP will be searched from their inception to October 2019. All randomized controlled trials (RCTs) of BBTT for H-type hypertension will be included. The language is limited to Chinese and English. The primary outcome measure will be the major adverse cardiac and cerebral events (MACCE). The entire process will include study selection, data extraction, assessment of bias risk, data synthesis. Data analysis will be performed using RevMan V.5.3.5 (The Cochrane Collaboration, Oxford, UK).ResultsThis study will evaluate the efficacy and safety of BBTT in the treatment of H-type hypertension from several aspects, including MACCE, blood pressure (BP), blood lipids, inflammation indicators and homocysteine (Hcy).ConclusionThis systematic review will provide evidence for determining whether or not BBTT is an effective and safe intervention for H-type hypertension.Prospero Registration NumberPROSPERO CRD 42019131491.

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