• J Clin Anesth · Feb 2012

    Case Reports

    Propofol-related infusion syndrome induced by "moderate dosage" in a patient with severe head trauma.

    • Thorsten Annecke, Peter Conzen, and Ludwig Ney.
    • Department of Anesthesiology, Ludwig-Maximilians-University Munich, D-80336 Munich, Germany. thorsten.annecke@med.uni-muenchen.de
    • J Clin Anesth. 2012 Feb 1;24(1):51-4.

    AbstractPropofol is widely used for sedating critically ill adult patients because of its rapid onset and short recovery times, even after prolonged use. Propofol may be associated with a life-threatening syndrome, propofol-related infusion syndrome (PRIS), which includes cardiac failure, severe metabolic acidosis, renal failure, and rhabodomyolysis. The pathophysiology is incompletely understood. Propofol-related infusion syndrome seems to be dose-related, and it occurs generally in patients undergoing long-term (> 48 hrs) sedation at higher doses (> 4 mg/kg/hr). A case of PRIS in a patient after severe head injury is presented.Copyright © 2012 Elsevier Inc. All rights reserved.

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