• Ichraf Kraoua, Jérôme Stirnemann, Maria João Ribeiro, Tiphaine Rouaud, Marc Verin, Agnès Annic, Christian Rose, Luc Defebvre, Liliane Réménieras, Michaël Schüpbach, Nadia Belmatoug, Marie Vidailhet, and Frédéric Sedel.
• Federation of Nervous System Diseases, Reference Center for Lysosomal Diseases, Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, France.
• Mov. Disord. 2009 Jul 30; 24 (10): 1524-30.

AbstractParkinsonism has been described in patients with Gaucher's disease (GD). We reviewed the 10 cases of patients with both parkinsonism and GD recorded in the French national GD registry, as well as 49 previously published cases. Relative to the general population, parkinsonism in GD patients (1) was more frequent, (2) occurred at an earlier age, (3) responded less well to levodopa, and (4) was more frequently associated with signs of cortical dysfunction. Enzyme replacement therapy (ERT) and substrate reduction therapy (SRT) were ineffective on GD-associated parkinsonism, suggesting that parkinsonism itself is not an indication for ERT or SRT in this setting.Copyright 2009 Movement Disorder Society.

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