• N. Engl. J. Med. · Feb 2015

    Anesthetic neurotoxicity--clinical implications of animal models.

    • Bob A Rappaport, Santhanam Suresh, Sharon Hertz, Alex S Evers, and Beverley A Orser.
    • From the Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD (B.A.R., S.H.); Northwestern University Feinberg School of Medicine, Chicago (S.S.); Washington University School of Medicine, St. Louis (A.S.E.); and the Department of Anesthesia and Physiology, University of Toronto, Toronto (B.A.O.).
    • N. Engl. J. Med.. 2015 Feb 26;372(9):796-7.

    AbstractSome anesthetics and sedatives have been shown to cause neurotoxic effects in laboratory animals. The FDA collaboration SmartTots recommends undertaking large-scale clinical studies and avoiding nonurgent surgical procedures requiring anesthesia in children younger than 3 years of age.

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