• Bader Faiyaz Zuberi, Majid Ahmed Shaikh, Faiza Sadaqat Ali, Tazeen Rasheed, and Zunaira Nawaz.
• Bader Faiyaz Zuberi, Department of Medicine, Dow University of Health Sciences, Karachi, Pakistan.
• Pak J Med Sci. 2020 Jan 1; 36 (2): 172-176.

ObjectiveTo determine effect of pre-endoscopy intake of simethicone solution on endoscopic mucosal visibility.MethodologyA randomized, single blinded placebo control trial was done in patients undergoing oesophago-gastro-duodenoscopy for any indication at DOTs Endoscopy Suite, CHK during the period of April to June 2019. Informed consent was taken. Patients were randomly allocated in two groups. Group-A received placebo while Group-B received Simethicone. Evaluation of mucosal visibility was assessed at 4 sites (oesophagus, fundus, antrum & duodenum) by previously validated scoring. Mean of visibility scores were compared in two groups.ResultsTwo hundred and forty-eight patients were inducted and randomly allocate to two groups of 124 each. Mean of total sum of scores in Group-A was 8.14 ±2.44 and that of Group-B was 5.80 ±1.75 (p<0.001). Adequate visibility in Group-A was seen in 41.1% and that in Group-B was 78.2% (p<0.001).ConclusionUse of Simethicone significantly improves mucosal visibility during OGD.Copyright: © Pakistan Journal of Medical Sciences.

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