• Julia K Winkler, Annika Woehning, Jobst-Hendrik Schultz, Maik Brune, Nigel Beaton, Tenagne Delessa Challa, Stella Minkova, Eva Roeder, Peter P Nawroth, Hans-Christoph Friederich, Christian Wolfrum, and Got... more tfried Rudofsky. less
• Department of Medicine I and Clinical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany.
• Nutrition. 2012 Oct 1;28(10):996-1001.

ObjectiveThe A1 allele of the TaqIA polymorphism in the dopamine D2 receptor gene (rs1800497) has been associated with obesity. However, the effect of the polymorphism on the success in weight loss and/or weight maintenance during weight-loss programs has not been evaluated thus far.MethodsThe rs1800497 was genotyped in 202 (135 female, 67 male) severely obese individuals with an initial body mass index of 41.7 ± 0.5 kg/m² who participated in a weight-loss program consisting of a weight-loss phase with a formula diet (12 wk) and a weight-maintenance phase (40 wk). Measurements were collected at baseline, after the weight-loss phase, and at the end of the weight-maintenance phase at 1 y.ResultsGenotyping revealed 4 A1A1, 67 A1A2, and 131 A2A2 genotype carriers. Of the 202 subjects in the program, 66.8% completed the program and 33.2% terminated prematurely. Neither the attrition rate (P = 0.44) nor the overall weight loss was influenced by the different genotypes (P = 0.96). However, younger A1⁺ participants (A1A1 and A1A2) had a higher body mass index at all time points (baseline, P = 0.04; after weight loss, P = 0.05; after weight maintenance, P = 0.02). They also showed less overall weight loss (P = 0.05), which derived mainly from a greater weight regain during the maintenance phase (P = 0.02).ConclusionIn this program, younger A1⁺ participants exhibited problems in maintaining weight loss during a weight-loss program.Copyright © 2012 Elsevier Inc. All rights reserved.

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