• Kevin C Maki, Glenn R Gibson, Robin S Dickmann, Cyril W C Kendall, C-Y Oliver Chen, Adele Costabile, Elena M Comelli, Diane L McKay, Nelson G Almeida, David Jenkins, Gordon A Zello, and Jeffrey B Blumberg.
• Biofortis-Provident Clinical Research, Glen Ellyn, Illinois, USA. KMaki@ProvidentCRC.com
• Nutrition. 2012 Nov 1;28(11-12):1115-21.

ObjectiveWe assessed whether a wheat bran extract containing arabino-xylan-oligosaccharide (AXOS) elicited a prebiotic effect and influenced other physiologic parameters when consumed in ready-to-eat cereal at two dose levels.MethodsThis double-blind, randomized, controlled, crossover trial evaluated the effects of consuming AXOS at 0 (control), 2.2, or 4.8 g/d as part of ready-to-eat cereal for 3 wk in 55 healthy men and women. Fecal microbial levels, postprandial serum ferulic acid concentrations, and other physiologic parameters were assessed at the beginning and end of each condition.ResultsThe median bifidobacteria content of stool samples (log₁₀/grams of dry weight [DW]) was found to be higher in the subjects consuming the 4.8-g/d dose (10.03) than in those consuming 2.2 g/d (9.93) and control (9.84, P < 0.001). No significant changes in the populations of other fecal microbes were observed, indicating a selective increase in fecal bifidobacteria. Postprandial ferulic acid was measured at 120 min at the start and end of each 3-wk treatment period in subjects at least 50 y old (n = 37) and increased in a dose-dependent manner (end-of-treatment values 0.007, 0.050, and 0.069 μg/mL for the control, AXOS 2.2 g/d, and AXOS 4.8 g/d conditions, respectively, P for trend < 0.001).ConclusionThese results indicate that AXOS has prebiotic properties, selectively increasing fecal bifidobacteria, and increases postprandial ferulic acid concentrations in a dose-dependent manner in healthy men and women.Copyright © 2012 Elsevier Inc. All rights reserved.

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