• Farzad Khademi, Hamid Vaez, Amir Abbas Momtazi-Borojeni, Araz Majnooni, Maciej Banach, and Amirhossein Sahebkar.
• Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.
• Arch Med Sci. 2019 Jul 1; 15 (4): 902-911.

IntroductionThe present study aimed to assess the prevalence and association of various bacterial infections with cardiovascular disease (CVD) in Iran.Material And MethodsAn electronic search was performed using related keywords in the national and international databases up to June 30, 2017. Out of the 1807 articles found on the associations between bacterial infections and CVD, 20 relevant studies were selected for the meta-analysis.ResultsThe prevalence of bacterial infections was higher in case groups compared with the control groups. Odds ratios for assessing the association between Chlamydia pneumonia infection and CVD based on PCR, IgG and IgA tests were 7.420 (95% CI: 3.088-17.827), 3.710 (95% CI: 1.361-10.115) and 2.492 (95% CI: 1.305-4.756), respectively. Moreover, the calculated odds ratio for Mycoplasma pneumonia infection was 1.815 (95% CI: 0.973-3.386). For Helicobacter pylori infection, odds ratios based on IgG and IgA tests were 3.160 (95% CI: 1.957-5.102) and 0.643 (95% CI: 0.414-0.999), respectively.ConclusionsThe present meta-analysis suggested that there was a significant association between H. pylori, C. pneumonia and M. pneumonia infections and CVD in Iran. These findings confirm the potential role of bacterial infections as predisposing factors for CVD.

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