• E Westhall, I Rosén, M Rundgren, J Bro-Jeppesen, J Kjaergaard, C Hassager, H Lindehammar, J Horn, S Ullén, N Nielsen, H Friberg, and T Cronberg.
• Lund University, Skane University Hospital, Department of Clinical Sciences, Clinical Neurophysiology, Lund, Sweden. Electronic address: erik.westhall@med.lu.se.
• Clin Neurophysiol. 2018 Aug 1; 129 (8): 1660-1668.

ObjectiveInvestigate the temporal development of EEG and prognosis.MethodsProspective observational substudy of the Target Temperature Management trial. Six sites performed simplified continuous EEG-monitoring (cEEG) on comatose patients after cardiac arrest, blinded to treating physicians. We determined time-points of recovery of a normal-voltage continuous background activity and the appearance of an epileptiform EEG, defined as abundant epileptiform discharges, periodic/rhythmic discharges or electrographic seizure activity.Results134 patients were included, 65 had a good outcome. Early recovery of continuous background activity (within 24 h) occurred in 72 patients and predicted good outcome since 55 (76%) had good outcome, increasing the odds for a good outcome seven times compared to a late background recovery. Early appearance of an epileptiform EEG occurred in 38 patients and 34 (89%) had a poor outcome, increasing the odds for a poor outcome six times compared to a late debut. The time to background recovery and the time to epileptiform activity were highly associated with outcome and levels of neuron-specific enolase. Multiple regression analysis showed that both variables were independent predictors.ConclusionsTime to epileptiform activity and background recovery are independent prognostic indicators.SignificancePatients with early background recovery combined with late appearance of epileptiform activity may have a good outcome.Copyright © 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

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