• Fatih Balaban, Seyhan Yağar, Ayşegül Özgök, Mihrican Koç, and Hayriye Güllapoğlu.
• Department of Anesthesiology and Reanimation, Türkiye Yüksek dIhtisas Education and Research Hospital, Sıhhıye 06100, Ankara, Turkey.
• J Clin Anesth. 2012 May 1;24(3):175-8.

Study ObjectiveTo determine the efficacy of two different doses (150 mg and 300 mg) of preoperative pregabalin on pain relief and total opioid consumption after laparoscopic cholecystectomy.DesignProspective, randomized, placebo-controlled, double-blinded study.SettingTraining and research hospital.Patients90 adult, ASA physical status 1 and 2 patients.InterventionsPatients were randomly assigned to three groups to receive orally one hour before surgery, a placebo (Group 1), pregabalin 150 mg (Group 2), or pregabalin 300 mg (Group 3). Patients were observed for pregabalin side effects, somnolence via Ramsay Sedation Scale, dizziness, confusion, and ataxia.MeasurementsIn the operating room, heart rate and noninvasive systolic and diastolic blood pressures were measured. Visual analog scale (VAS), Ramsay Sedation Scale, and Aldrete scores were also recorded on arrival at the Postanesthesia Care Unit (time 0), 15, 30, 60, 120 minutes and 3, 4, 6, 8, 10, 12 and 24 hours after surgery. Additional doses of drugs (fentanyl and/or metoclopramide) were also recorded.Main ResultsPreemptive pregabalin decreased pain scores and postoperative fentanyl consumption in patients after laparoscopic cholecystectomy in a dose-dependent manner. There were no differences between the groups in side effects.ConclusionPreoperative pregabalin may be a useful analgesic for patients after laparoscopic cholecystectomy, as it lowers pain intensity and opiod consumption, and does not increase the frequency of side effects.Copyright © 2012 Elsevier Inc. All rights reserved.

This article appears in the collection: Does perioperative pregabalin reduce postoperative pain?.

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