• Internal medicine · Feb 2021

    Case Reports

    Alectinib-induced Immune Hemolytic Anemia in a Patient with Lung Adenocarcinoma.

    • Joe Okumoto, Shinjiro Sakamoto, Takeshi Masuda, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Taku Nakashima, Hiroshi Iwamoto, Noriyasu Fukushima, Kazunori Fujitaka, Hironobu Hamada, and Noboru Hattori.
    • Department of Molecular and Internal Medicine, Hiroshima University Hospital, Japan.
    • Intern. Med. 2021 Feb 15; 60 (4): 611615611-615.

    AbstractDrug-induced immune hemolytic anemia (DIIHA) is a rare condition with an increasing incidence associated with the frequent use of certain drugs. An 85-year-old woman with lung adenocarcinoma prescribed alectinib complained of dyspnea on exertion at our hospital. Based on her laboratory tests results on admission, we focused on the clinical course of anemia and hemolysis progression after alectinib administration. The patient's anemia and hemolysis gradually improved after discontinuation of alectinib, leading to a diagnosis of alectinib-induced IHA, presented here as the first case encountered in a patient with lung adenocarcinoma. Furthermore, we discuss the importance of correlating clinical laboratory findings in DIIHA.

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