• Erina Joo, Shunsuke Yamane, Akihiro Hamasaki, Norio Harada, Tetsuro Matsunaga, Atsushi Muraoka, Kazuyo Suzuki, Daniela Nasteska, Toru Fukushima, Tatsuya Hayashi, Hidemi Tsuji, Kenichiro Shide, Kinsuke Tsuda, and Nobuya Inagaki.
• Laboratory of Sports and Exercise Medicine, Graduate School of Human and Environmental Studies, Kyoto University, Kyoto, Japan.
• Nutrition. 2013 Mar 1;29(3):549-55.

ObjectiveUlcerative colitis is a chronic recurrent disease characterized by acute inflammation of the colonic mucosa. In Japan, a dietary supplementation product enriched with glutamine, dietary fiber, and oligosaccharide (GFO) is widely applied for enteral nutrition support. These three components have been suggested to improve intestinal health. In this study, we investigated whether GFO has suppressive effects on mucosal damage in ulcerative colitis in an experimental mouse model.MethodsC57BL/6 mice received 2.5% dextran sulfate sodium in drinking water for 5 d to induce colitis. Then, they were given 0.25 mL of GFO or a 20% glucose solution twice daily for 10 d. Another set of mice receiving unaltered drinking water was used as the normal control group.ResultsThe body weight loss and disease activity index were significantly lower in the GFO-treated mice compared with the glucose-treated mice (P < 0.05). The decrease in colon length induced by dextran sulfate sodium was significantly alleviated in GFO-treated mice compared with glucose-treated mice (P < 0.01). In addition, the histologic findings showed that intestinal inflammation was significantly attenuated in mice treated with GFO. Furthermore, treatment with GFO significantly inhibited the dextran sulfate sodium-induced increase in the mRNA expression of interleukin-1β.ConclusionThese results suggest that GFO has potential therapeutic value as an adjunct therapy for ulcerative colitis.Copyright © 2013 Elsevier Inc. All rights reserved.

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