• Dimitrios Samaras, Nikolaos Samaras, Pierre-Olivier Lang, Laurence Genton, Emilia Frangos, and Claude Pichard.
• Clinical Nutrition, Department of Medical Specialties, Geneva University Hospital, Geneva, Switzerland.
• Nutrition. 2013 Apr 1;29(4):605-10.

AbstractVitamins and trace elements are essential to the body, however, deficiencies are frequently observed in the general population. Diet is mostly responsible for these deficiencies but drugs also may play a significant role by influencing their metabolism. These effects are rarely assessed in clinical practice, in part because of limited data available in the literature. Drug-induced micronutrient depletions, however, may be the origin of otherwise unexplained symptoms that might sometimes influence medication compliance. We present various examples of widely prescribed drugs that can precipitate micronutrient deficiencies. This review aims at sensitizing physicians on drug-micronutrient interactions. High-risk population groups also are presented and supplementation protocols are suggested.Copyright © 2013 Elsevier Inc. All rights reserved.

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