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- Marcella Martinelli, Luca Scapoli, Angela Maria Grazia Pacilli, Paolo Carbonara, Ambra Girardi, Gabriella Mattei, Maria Teresa Rodia, and Rossella Solmi.
- Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, Bologna, Italy ; Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy.
- J Res Med Sci. 2015 Jan 1; 20 (1): 93-6.
BackgroundFor the first time we tested an association between the human multidrug resistance gene 1 (MDR1) polymorphisms (SNPs) and idiopathic pulmonary fibrosis (IPF). Several MDR1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics.Materials And MethodsWe genotyped three MDR1 polymorphisms of 48 IPF patients and 100 control subjects with Italian origins.ResultsNo evidence of association was detected.ConclusionThere are 50 known MDR1 SNPs, and their role is explored in terms of the effectiveness of drug therapy. We consider our small-scale preliminary study as a starting point for further research.
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