• J Res Med Sci · Jan 2015

    Human Multidrug Resistance 1 gene polymorphisms and Idiopathic Pulmonary Fibrosis.

    • Marcella Martinelli, Luca Scapoli, Angela Maria Grazia Pacilli, Paolo Carbonara, Ambra Girardi, Gabriella Mattei, Maria Teresa Rodia, and Rossella Solmi.
    • Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Unit of Histology, Embryology and Applied Biology, Bologna, Italy ; Centre of Molecular Genetics, CARISBO Foundation, University of Bologna, Bologna, Italy.
    • J Res Med Sci. 2015 Jan 1; 20 (1): 93-6.

    BackgroundFor the first time we tested an association between the human multidrug resistance gene 1 (MDR1) polymorphisms (SNPs) and idiopathic pulmonary fibrosis (IPF). Several MDR1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics.Materials And MethodsWe genotyped three MDR1 polymorphisms of 48 IPF patients and 100 control subjects with Italian origins.ResultsNo evidence of association was detected.ConclusionThere are 50 known MDR1 SNPs, and their role is explored in terms of the effectiveness of drug therapy. We consider our small-scale preliminary study as a starting point for further research.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…