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- Mari Takahashi, Yukihiro Horio, Takahisa Takihara, Keito Enokida, Masashi Miyaoka, Kenichi Hirabayashi, Kana Ohshinden, Shigeaki Hattori, Fuminari Takahashi, Genki Takahashi, Jun Tanaka, Hiroto Takiguchi, Kyoko Niimi, Yoko Ito, Naoki Hayama, Tsuyoshi Oguma, and Koichiro Asano.
- Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
- Intern. Med. 2021 Feb 15; 60 (4): 617-621.
AbstractA 72-year-old man was treated with prednisolone and cyclosporine A for idiopathic pulmonary fibrosis. A nodule with a diameter of 19 mm was found in the right lung and diagnosed as lung squamous cell carcinoma. Anti-cancer treatments were not performed because of the presence of advanced interstitial pneumonia and chronic respiratory failure. Cyclosporine A was tapered to avoid suppression of anti-tumor immunity, and pirfenidone was initiated. Within 2 months, the tumor had shrunk to 10 mm in diameter and remained regressed for 9 months. This is the first report of a non-hematologic solid organ tumor responding to the discontinuation of immunosuppressants.
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