• Cristiane Chiantelli Claudio, Rose Vega Patin, Cecília Zanin Palchetti, Daisy Maria Machado, Regina Célia de Menezes Succi, and Fernanda Luisa Ceragioli Oliveira.
• Division of Nutrition, Department of Pediatrics, UNIFESP/EPM, São Paulo, Brazil.
• Nutrition. 2013 Jul 1;29(7-8):1020-3.

ObjectiveThe objective of the study was to assess the nutritional status and metabolic alterations in HIV-exposed uninfected (HIVe) children compared with HIV-unexposed (HIVn) children.MethodsA cross-sectional study was carried out with 76 children distributed into two groups: HIVe (n = 31) and HIVn (n = 45). Biochemical data (hematologic test, lipid profile, insulin resistance, hepatic profile, and C-reactive protein) were evaluated. Anthropometric parameters and body composition analyses were performed.ResultsThe groups were similar regarding body mass index-for-age z-scores (P = 0.297) and height-for-age z-scores (P = 0.666). HIVe had a higher dyslipidemia prevalence (38.7% versus 11.1%; P = 0.010), altered total cholesterol (TC) values (19.4% versus 2.2%; P = 0.016) higher LDL-C mean levels (97.8 mg/dl versus 86 mg/dl; P = 0.028), borderline low-density lipoprotein cholesterol (LDL-C) (40% versus 14%; P = 0.011) and TC (41.9% versus 20%; P = 0.038) compared with HIVn.ConclusionDespite the similar nutritional status between groups, our data clearly demonstrated a higher prevalence of dyslipidemia, altered TC, higher LDL-C levels and also LDL-C and TC borderline values in HIVe children.Copyright © 2013 Elsevier Inc. All rights reserved.

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