• Satyan Nanda, Rahul Handa, Atul Prasad, Rajiv Anand, Dhruv Zutshi, Sujata K Dass, Prabhjeet Kaur Bedi, Aarti Pahuja, Pankaj Kumar Shah, and Bipan Sharma.
• Department of Neurology, BLK Super Speciality Hospital, New Delhi, India.
• Am J Emerg Med. 2021 Jan 1; 39: 125-128.

BackgroundGlobally, more than 12 million people have been infected with COVID -19 infection till date with more than 500,000 fatalities. Although, Covid-19 commonly presents with marked respiratory symptoms in the form of cough and dyspnoea, a neurotropic presentation has been described of late as well.ObjectiveIn this brief communication we report four cases of Covid-19 who presented to our hospital with features suggestive of Guillain-Barre Syndrome (GBS).DiscussionThe mechanisms by which SARS-CoV-2 causes neurologic damage are multifaceted, including direct damage to specific receptors, cytokine-related injury, secondary hypoxia, and retrograde travel along nerve fibres. The pathogenesis of GBS secondary to Covid-19 is not well understood. It is hypothesised that viral illnesses related GBS could be due to autoantibodies or direct neurotoxic effects of viruses.ConclusionNervous system involvement in Covid-19 may have been grossly underestimated. In this era of pandemic, it is very important for the physicians to be aware of association of GBS with Covid-19, as early diagnosis and treatment of this complication could have gratifying results. To the best of our knowledge, this is the first such case series of Guillain-Barre Syndrome associated with Covid-19 to be reported from India.Copyright © 2020 Elsevier Inc. All rights reserved.

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