• Jingya Chen, Wei Zhang, Hu Chen, Yajing Wang, Zhengjun Li, Huiming Wu, Jian Zhang, and Zhongqiu Wang.
• Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing.
• Medicine (Baltimore). 2020 Oct 9; 99 (41): e22666.

RationaleGiant multilocular prostatic cystadenoma (GMPC) is a rare type of prostatic epithelial neoplasm. Thus, the imaging features of this condition are not well known. We report the imaging and clinical manifestations of a case of GMPC.Patient ConcernsThe case reported here relates to a 71-year-old man who complained of urination frequency and excessive urination at night. He underwent computed tomography (CT) and magnetic resonance imaging (MRI) examination before surgery, both tests revealed a mass body in the prostate.DiagnosisUltrasound-guided fine needle aspiration was performed and a diagnosis of GMPC was made by histological examination.InterventionsThe patient received radical pelvic tumor resection successfully.OutcomesTwo months after surgery, the follow-up CT and magnetic MRI re-examination found no signs of recurrence.LessonsGMPC is a rare prostatic neoplasm with atypical clinical symptoms. MRI provides valuable information about GMPC. In case of a giant multilocular prostatic mass with well-defined boundary and abundant vascularity, benign feature on diffusion-weighted imaging, GMPC should be considered.

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