• Rachel Hill, Tyler Hamby, Danielle Johnson, Charles Boren, Heather Downs, and Anish Ray.
• Department of Pediatric Hematology/Oncology, Cook Children's Health Care System, Fort Worth, Texas.
• Nutrition. 2021 Jan 1; 81: 110937.

ObjectiveChildren with acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma often experience significant weight gain during induction therapy. However, a subgroup of patients may experience weight loss, which can impact outcomes; thus, identifying and understanding this underrecognized concern is important. Our aim was to identify the prevalence and predictors for weight loss during ALL induction therapy.MethodsThis was a single-institution retrospective study of 187 patients, ages 2 to 20 y, diagnosed with ALL or lymphoblastic lymphoma. We analyzed weight trends during induction therapy and predictors of weight loss.ResultsSignificant weight loss (≥5%) occurred in 17% of patients. Having high-risk disease, trisomy 21, overweight/obese status at the time of diagnosis, and/or hyperglycemia were positively associated with weight loss and negatively associated with weight gain during induction therapy.ConclusionFuture studies should aim to better understand the etiology and importance of weight loss during induction therapy.Copyright © 2020 Elsevier Inc. All rights reserved.

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