• Jing Lu, Jin-Feng Wang, Chao-Lin Guo, Qin Yin, Wei Cheng, and Bin Qian.
• From the The Yancheng Clinical College of Xuzhou Medical University, The First people's Hospital of Yancheng, Yancheng (JL, BQ), The Affiliated Hospital of Xuzhou Medical University (JL, QY, WC), Xuzhou Central Hospital (JFW) and the People's Hospital of Kizilsu Kirghiz Autonomous Prefecture, Xinjiang, PR China (CLG, WC).
• Eur J Anaesthesiol. 2021 Mar 1; 38 (Suppl 1): S1-S8.

BackgroundPrevious data show that lidocaine or magnesium has unique characteristics of stress inhibition and antiinflammation.ObjectiveWe aimed to observe the effects of lidocaine or magnesium on the quality of recovery (QoR) after laparoscopic cholecystectomy.DesignSingle-centre, prospective, randomised, double-blind study.SettingThe Affiliated Hospital of Xuzhou Medical University from March 2019 to October 2019.PatientsOne hundred and fourteen patients scheduled for laparoscopic cholecystectomy.InterventionThe enrolled patients were randomly divided into three groups. Lidocaine (group L), magnesium sulphate (group M) or 0.9% saline (group C) was administered intravenously 10 min before induction.Main Outcome MeasuresThe quality of recovery 15 (QoR-15) score, the Hospital Anxiety and Depression Scale (HADS), and the Numerical Rating Scale (NRS) score were selected. The usage of propofol and remifentanil, haemodynamic parameters, anaesthesia recovery parameters and adverse events were also evaluated.ResultsThe QoR-15 scores for group L (132.0) and group M (134.0) were 6 and 8 points higher than that of group C (126.0) on POD1 (postoperative day 1) (adjP < 0.05). However, the decrease of QoR-15 in Group L is less than the minimal clinically important difference (8).The NRS scores on POD1 in group C 3, were higher than other two groups (adjP < 0.05). The dosage of remifentanil in group L was lower than other two groups (adjP < 0.05).The physical independence of group L and group M and physical comfort of group M were improved compared with group C.ConclusionThe results show that magnesium sulphate improved the QoR through improving physical comfort and physical independence in patients after laparoscopic cholecystectomy. However, lidocaine had limited effects on QoR under current conditions.Trial RegistrationChiCTR1800019092 (www.chictr.org.cn).Clinical Trial Number And Registry UrlThe study was registered in the Chinese Clinical Trials Register (ChiCTR1800019092) https://www.chictr.org.cn.Copyright © 2020 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.

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